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用68Ga-DOTATOC PET/CT对胰腺非功能神经内分泌瘤进行不可逆转电穿孔的功能评估

Hind Ait Talhiq^1,2,3, Philippe Baltzinger⁴, Michaela Achille⁵

¹Nuclear Medicine and Molecular Imaging, ICANS.

Clinical nuclear medicine

|December 8, 2025

概括

穿皮不可逆电穿孔 (IRE) 为胰腺神经内分泌瘤 (pNETs) 提供了一种非热性除选择. 本案例研究表明,IRE实现了持久的瘤控制,PET/CT评估了功能反应.

科学领域:

在瘤学瘤学.
干预性放射学干预性放射学
核医学是一种核医学.

背景情况:

胰腺神经内分泌瘤 (pNETs) 是一种罕见的恶性瘤.
穿皮不可逆电穿孔 (IRE) 是一种非热性剥离技术,在胰腺癌中越来越受欢迎.
在pNET中IE的应用很少被记录下来.

研究的目的:

为一个不起作用的等级-1 pNET.NET 提供皮肤穿透性 IRE 的案例.
评估IRE在PNET治疗中的疗效和功能反应.
突出 PET/CT 在评估治疗结果中的作用.

主要方法:

一名75岁的男性患者患有非功能PNET,拒绝进行手术.
通过皮肤进行不可逆转的电穿孔 (IRE) 是主要治疗方式.
治疗后的评估包括体静止素受体PET/CT和对比度增强CT.

主要成果:

该患者在IRE后1个月内在PET/CT上显示出68Ga-DOTATOC摄入量的显著减少.
一年后在PET/CT上观察到稳定的残留活性,这表明持续的瘤控制.
与对比度增强的CT证实了治疗后瘤的完全脱细胞化.

结论:

皮肤内注射IRE显示了在胰腺神经内分泌瘤中实现持久瘤控制的潜力.
PET/CT提供了对IRE功能反应的有价值评估,补充了形态成像.
这个案例支持IRE作为选择的PNET患者的可行治疗选择.

关键词:

在 DOTATOC 里面,你会看到在这里,PET是PET.这是不可逆转的电穿孔.神经内分泌瘤是一个神经内分泌瘤.胰腺胰腺是什么

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