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Updated: Jan 9, 2026

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
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Published on: June 20, 2019

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调音瓶刷 聚合物架构和聚合物的组成 (?? 烯酸) 改善GDC-0810 药物溶性维护

Kaylee E Barr1, Elizabeth C Lopez2, Soumi Das2

  • 1Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Biomacromolecules
|December 8, 2025
PubMed
概括

聚合物结构和碳素酸含量显著影响无形固体分散 (ASD) 药物溶解. 瓶刷聚合物中碳酸盐基的增加提高了乳腺癌治疗药物的可溶性,如GDC-0810.

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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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