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在树突细胞中与HLA-DR结合的加勒-9控制着免疫突触的形成和T细胞的增殖

Andrea Rodgers-Furones1, Thijs Brands1, Guusje van Gameren1

  • 1Department of Medical BioSciences, Radboudumc, Nijmegen 6525GA, Netherlands.

Proceedings of the National Academy of Sciences of the United States of America
|December 8, 2025
PubMed
概括

树突细胞 (DCs) 中的细胞内甲蛋白-9 (gal9) 通过在免疫突触中组织HLA-DR,对CD4+ T细胞激活至关重要. 缺乏gal9的DC显示T细胞反应受损,瘤生长增加.

关键词:
在 HLA-DR 组合下,树突细胞的树突细胞.盖莱克因的使用方法免疫突触的突触发生.

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