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自动化光谱域与扫描源OCT血管学相对于玻璃眼的严重程度

Massimo A Fazio^1,2, Stuart K Gardiner², K S Reynoso Moreno¹

¹Department of Ophthalmology and Vision Science, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL.

Journal of glaucoma

|December 8, 2025

概括

通过OCT-A测量出的更高的辐射周周毛细血管密度与格劳科马患者的更好的视野指标有关. 两种光谱域和扫描源的OCT平台都显示出类似的诊断性能,支持OCT-A.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
玻璃眼研究研究玻璃眼研究

背景情况:

主要开角青光眼 (POAG) 是不可逆转失明的主要原因.
早期检测和监测青光眼的进展对于保持视力至关重要.
光学连贯断层扫描血管学 (OCT-A) 提供了视神经头部详细的微血管成像.

研究的目的:

评估OCT-A指标之间的关联,特别是辐射周毛细血管 (RPC) 密度和POAG患者的视野 (VF) 平均偏差 (MD).
在评估这种关联时,要比较光谱域OCT (SD-OCT) 和扫源OCT (SS-OCT) 平台的性能.

主要方法:

一项前性横截面研究,涉及18名患者 (28只眼睛) 患有POAG.
使用Topcon Maestro2 (SD-OCT) 和Topcon Triton (SS-OCT) 进行了OCT-A成像.
从以视神经头为中心的6x6毫米2扫描量化了RPC密度,并使用多变量线性混合效应模型分析了与VF参数 (MD,VFI,PSD) 的关联.

主要成果:

增加的RPC密度独立地与两种OCT-A平台的更好的视野指标相关.
每增加1%的RPC密度都与改善的MD,VFI和PSD值有关.
无论是SD-OCT还是SS-OCT系统在检测这些关联方面都表现出了可比的诊断性能.

结论:

来自OCT-A的RPC密度是初级开角青光眼中视野功能的显著且独立的相关值.
这些发现支持将OCT-A,包括自动化SD-OCT系统,整合到常规的青光眼评估和查中.
不同的OCT-A技术之间可比的诊断性能突出显示了青光眼中微血管评估的稳定性.

关键词:

光学连贯性断层扫描血管图谱主要的开放角度光眼 (Glaucoma)辐射周毛细管毛细管的密度在光谱域的OCT.扫过来源的OCT.视野视野视野视野视野

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