内膜异位症对炎症性肠道疾病的进展的影响:多中心回顾性研究
Lucas Guillo1, Oumaya El Oumami2, Philippe Seksik3
1Department of Gastroenterology, University Hospital of Marseille Nord, University of Aix-Marseille, Marseille, France.
Clinical and translational gastroenterology
|December 8, 2025
概括
患有子宫内膜异位症和炎症性肠道疾病 (IBD) 的女性在克罗恩病患者中表现出不那么严重的疾病过程. 子宫内膜异位症没有对IBD进展产生负面影响,免疫抑制剂和生物药物的使用减少.
科学领域:
- 胃肠病学 胃肠病学
- 妇科 妇科 妇科 妇科
- 临床医学 临床医学
背景情况:
- 患有子宫内膜异位症的女性面临患炎症性肠病 (IBD) 的风险增加.
- 了解子宫内膜异位症对IBD进展的影响对于患者管理至关重要.
研究的目的:
- 研究子宫内膜异位症如何影响炎症性肠道疾病的临床过程和进展.
- 为了比较患有子宫内膜异位症和没有子宫内膜异位症的患者的IBD结局.
主要方法:
- 一项回顾性队列研究涉及207名患有子宫内膜异位症和IBD的患者,与409名没有子宫内膜异位症的IBD患者进行了匹配.
- 从法国和比利时的18个IBD中心收集的数据 (2022年6月至2023年3月).
- 使用综合严重性标准评估IBD进展,包括肠道损伤或需要肠道手术.
主要成果:
- 患有子宫内膜异位症的克朗氏病 (CD) 患者表现出不那么严重的疾病过程 (HR=0.68,p=0.011).
- 患有子宫内膜异位症的性结肠炎 (UC) 患者的病程没有显著不同 (HR=1.73,p=0.20),尽管直肠炎更频繁.
- 患有子宫内膜异位症的患者对CD和UC的免疫抑制剂和生物药物的暴露显著减少.
结论:
- 子宫内膜异位症不会对IBD的整体过程产生负面影响.
- 患有子宫内膜异位症的CD患者经历了不那么严重的疾病进展.
- 减少免疫抑制剂和生物药物的使用,观察到IBD患者与子宫内膜异位症.
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