拉诺斯坦三烯酸盐的低血糖效应来自Ganoderma lingzhi的果实体
Jiaocen Guo1, Li Yang1, Mingli Han1
1Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
Bioorganic chemistry
|December 8, 2025
概括
甘菌产生了五种新的lanostane三类化合物. 化合物7抑制蛋白氨酸酸酶1B和α-葡萄糖酶,降低小鼠的血糖水平.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 药用菌类 药用菌类 药用菌类
背景情况:
- 甘是一种药用,在亚洲因其活力和长寿而受到重视.
- 灵芝 (Ganoderma lingzhi) 是一种以其生物活性化合物而闻名的物种.
研究的目的:
- 为了隔离和表征来自Ganoderma lingzhi的新化合物.
- 评估这些化合物对PTP1B和α-葡萄糖酶的抑制潜力.
- 为了研究有前途的化合物的双目标抑制机制.
主要方法:
- 使用光谱分析 (NMR,ECD) 来分离和阐明化合物的结构.
- 对PTP1B和α-葡萄糖酶的酶抑制试验.
- 酶动力学,分子对接和动态模拟.
- 在小鼠体内进行葡萄糖耐受性测试.
主要成果:
- 分离了五种新的lanostane三烯酸 (ganoderenic酸J-N) 和42种已知的化合物.
- 化合物7显示了PTP1B的非竞争性抑制 (IC50 = 5.95 μM).
- 化合物7,11,14-17和22抑制了α-葡萄糖酶 (IC50范围:32.72146.10微米).
- 化合物7在小鼠中证明了双重目标抑制和降低饭后血糖水平.
结论:
- 甘菌 (Ganoderma lingzhi) 是一种新型生物活性三基的来源.
- 化合物7对PTP1B和α-葡萄糖酶具有双重抑制活性,这表明它有可能控制血糖水平.
- 对化合物7的治疗潜力进行进一步研究是有必要的.
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