对pH值敏感的酸盐 - 碳聚水凝贴片的设计,用于伤口愈合应用
Raffaella De Piano1, Francesco Barra1, Diego Caccavo1
1Department of Industrial Engineering, University of Salerno, 84084 Fisciano, SA, Italy.
International journal of pharmaceutics
|December 8, 2025
概括
新的pH敏感的水凝伤口敷料只有在感染时才会释放消毒剂. 这些智能带通过响应伤口pH值的变化来改善感染管理和更快的愈合.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 伤口愈合技术 伤口愈合技术
背景情况:
- 智能伤口带提供先进的感染管理.
- 响应pH的材料可以检测与感染相关的性条件.
研究的目的:
- 开发pH敏感的水凝贴片,用于控制抗菌剂释放.
- 为了研究甲蓝从酸盐-碳聚合物复合物中的释放动力学.
主要方法:
- 制造阿尔金酸盐-卡尔博波尔水凝贴片.
- 在pH 5和pH 8下进行的胀,侵蚀和甲基蓝释放研究.
- 药物释放动力学的数学建模.
主要成果:
- 水凝贴片在酸性pH (5) 时显示稳定性,在性pH (8) 时显示显著的胀和侵蚀.
- 在pH 8时观察到完全释放的甲基蓝色,由pH诱导的侵蚀驱动.
- 数学模型准确地描述了实验释放数据,证实了侵蚀控制释放.
结论:
- 碳聚-酸盐复合材料作为有效的响应pH的伤口剂.
- 这些敷料显示了抗菌剂的受控,pH触发的释放.
- 开发的系统显示了增强伤口感染管理和愈合的潜力.
相关概念视频
pH
The potential of hydrogen (pH) is a measure of the acidity or basicity of a water-based solution determined by the concentration of hydronium ions (H3O+). In one liter of pure water at neutral pH, there are 1×10−7 moles of hydronium ions. However, the extensive range of hydronium ion concentrations present in water-based solutions makes measuring pH in moles cumbersome. Therefore, a pH scale was developed to convert moles of hydronium ions into the negative logarithm of the hydronium ion...
Determining the pH of Salt Solutions
The pH of a salt solution is determined by its component anions and cations. Salts that contain pH-neutral anions and the hydronium ion-producing cations form a solution with a pH less than 7. For example, in ammonium nitrate (NH4NO3) solution, NO3− ions do not react with water whereas NH4+ ions produce the hydronium ions resulting in the acidic solution. In contrast, salts that contain pH-neutral cations and the hydroxide ion-producing anions form a solution with a pH greater than 7. For...
Buffers
A solution containing appreciable amounts of a weak conjugate acid-base pair is called a buffer solution, or a buffer. Buffer solutions resist a change in pH when small amounts of a strong acid or a strong base are added. A solution of acetic acid and sodium acetate is an example of a buffer that consists of a weak acid and its salt: CH3COOH (aq) + CH3COONa (aq). An example of a buffer that consists of a weak base and its salt is a solution of ammonia and ammonium chloride: NH3 (aq) + NH4Cl...
Buffer Effectiveness
Buffer solutions do not have an unlimited capacity to keep the pH relatively constant . Instead, the ability of a buffer solution to resist changes in pH relies on the presence of appreciable amounts of its conjugate weak acid-base pair. When enough strong acid or base is added to substantially lower the concentration of either member of the buffer pair, the buffering action within the solution is compromised.
The buffer capacity is the amount of acid or base that can be added to a given volume...
The buffer capacity is the amount of acid or base that can be added to a given volume...
pH
The potential of hydrogen (pH) is a measure of the acidity or basicity of a water-based solution determined by the concentration of hydronium ions (H3O+). In one liter of pure water at neutral pH, there are 1×10−7 moles of hydronium ions. However, the extensive range of hydronium ion concentrations present in water-based solutions makes measuring pH in moles cumbersome. Therefore, a pH scale was developed to convert moles of hydronium ions into the negative logarithm of the hydronium ion...
Bicarbonate-Carbonic Acid Buffer
The carbonic acid-bicarbonate buffer system is critical for maintaining the body's pH balance. It operates on the equilibrium:


