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运动训练对创伤后脑损伤中海马神经保护的分子调节:系统性审查

Farhan Yousaf¹, Sean Kao², Shahid Ishaq³

¹Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan.

Experimental neurology

|December 8, 2025

概括

运动训练通过减少氧化应激和神经炎症有利于创伤性脑损伤 (TBI) 恢复. 这种干预增强了TBI动物的线粒体功能,神经发生和认知功能.

科学领域:

神经科学是一个神经科学.
运动生理学运动生理学
神经生物学神经生物学神经生物学

背景情况:

创伤性脑损伤 (TBI) 导致氧化应激,神经炎症,细胞死亡和线粒体功能障碍,导致海马体损伤.
运动训练是TBI后神经保护的潜在非药物治疗方法.

研究的目的:

系统地审查运动训练对TBI动物模型中神经生物学机制和认知功能的影响.

主要方法:

在PubMed,Embase和Web of Science数据库中搜索到2025年7月,遵守PRISMA 2020指南.
包括44项涉及TBI后动物和各种运动干预措施 (轮子跑,跑步机,游泳) 的研究,持续7-94天.
使用CAMARADES检查清单评估研究质量.

主要成果:

运动训练降低了活性氧物种 (ROS),炎症和亡标志物,同时增加了TBI动物的抗氧化能力.
观察到增强的线粒体功能 (PGC-1α,电子运输系统活动) 和神经营养信号 (BDNF,TrkB,Synapsin-1).
运动后的干预观察到改善了认知功能,空间学习,记忆和减少了类似焦虑的行为.

结论:

运动训练有效地减轻了TBI后的氧化应激,神经炎症和亡.
它显著增强了线粒体功能,神经营养信号传递和神经发生.
运动训练在TBI动物模型中明显改善了认知功能和行为结果.

关键词:

进行有氧训练.认知功能认知功能神经新生是神经发生的过程.神经保护是一种神经保护.神经创伤是一种神经创伤.

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Traumatic Brain Injury l: Introduction

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