在过敏性鼻炎中重新平衡炎症利基"
1College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin 130117,China.
Clinica chimica acta; international journal of clinical chemistry
|December 8, 2025
概括
传统中国医学 (TCM) 通过调节肠道微生物群及其代谢物,影响第二组先天性淋巴细胞 (ILC2) 来影响过敏性鼻炎 (AR). 传统医学疗法可以通过向参与AR病变发生的微生物信号通路来恢复粘膜平衡.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 过敏性鼻炎 (AR) 的发病过程涉及居住微生物群,微生物衍生分子和2组先天性淋巴细胞 (ILC2) 之间的复杂相互作用.
- 传统中医 (TCM) 在调节免疫反应方面显示出潜力,但其在AR中的精确机制需要阐明.
研究的目的:
- 审查通过TCM影响AR中的微生物群-ILC2网络的信号轴.
- 探索微生物代谢物的作用,包括短链脂肪酸 (SCFA),胆汁酸和托代谢物,在TCM对AR的治疗作用中.
主要方法:
- 对TCM配方和植物化学品的临床前和新出现的临床数据的审查.
- 对参与TCM驱动的微生物组和代谢组变化的分子媒介的分析.
- 专注于信号通路,如HDAC抑制,SCFA受体信号,FXR/TGR5和AhR激活.
主要成果:
- 传统医疗干预与肠道和呼吸道微生物群的重塑有关,增加有益的代谢物,如SCFA,胆汁酸和内醇.
- 选择的TCM在临床前模型中显示了表皮上警信号 (TSLP/IL-33) 的直接减弱.
- 特定的分子媒介 (例如HDAC,GPR41/43,FXR/TGR5,AhR) 与微生物群-ILC2轴上的TCM作用有关.
结论:
- 传统医学提供基于机制的策略来抑制ILC2激活,并恢复AR中的粘膜平衡.
- 需要进一步的机理临床研究来确定因果关系并优化基于TCM的AR疗法.
关键词:
啊啊啊啊啊啊啊啊啊啊啊啊啊啊啊啊啊啊啊啊过敏性鼻炎是一种过敏性鼻炎.黄糖酸盐是什么 黄糖酸盐在 FXR 和 FXR 之间.在 GPR41 中使用.在 GPR43 中使用.在HDAC的基础上,HDAC是在 ILC2 中.短链脂肪酸 短链脂肪酸在TGR5中,TGR5是TGR5.传统的中国医学是传统的中国医学.更多相关视频
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