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机器学习预测压力诱导的D-二分体反应性在男性医生与或没有倦怠

Roland von Känel¹, Marie Gronemeyer¹, Claudia Zuccarella-Hackl¹

¹Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Seminars in thrombosis and hemostasis

|December 8, 2025

概括

急性情绪压力会增加血栓的风险,特别是在男性医生身上. 早期的逆境,酒精使用和压力激素的激增预测了这种增高的D-二次体反应,有助于识别那些有风险发生压力触发的心脏事件的人.

科学领域:

心脏病学心脏病学
心理神经内分泌学心理学
血液学血液学血液学

背景情况:

急性情绪压力是急性冠状动脉综合征 (ACS) 的已知触发因素之一.
D-二聚合物水平反映了压力期间的纤维素周转和凝血激活.
预测D-二次体应激反应的预测因子,特别是在高风险群体中,如患有倦怠症的男性医生,尚不清楚.

研究的目的:

在男性医生中确定D-二次体应激反应的预测因子.
研究人口,行为,心理和生理因素对急性压力的凝血反应的影响.

主要方法:

60名男性医生 (有或没有倦怠) 接受了特里尔社会压力测试.
在一个小时的时间内,在四个时间点测量了D-二聚合物和其他生物标志物.
拉索回归确定了关键预测因素,随后进行线性回归以估计效应大小.

主要成果:

D-二次体应激反应的关键预测因素包括压力前的D-二次体,酒精消费,压力前的皮质醇,压力诱导的上腺素 (EPI) 激增,以及不良童年经历 (ACE).
酒精消费,EPI激增和ACE与增加的D-二次体反应有关.
较高的D-二次元前应力与减弱的反应性有关,这些因素解释了D-二次元AUC变异的50.4%.

结论:

早期的逆境,酒精消费和交上腺激活显著影响应激诱导的凝血激活,如D-二次体活性所示.
这些已识别的预测因素可能有助于识别患有压力触发ACS的风险较高的个体.
研究结果表明,预防策略的潜在目标是旨在减轻与压力相关的心血管事件.

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