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"伯尔尼,做好准备",BEready,一个基于家庭的队列研究,用于瑞士的流行病准备研究:试点研究
Eva Maria Hodel1,2, Selina Wegmüller3,4,5, Franziska Iff3,2
1Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland evamaria.hodel@unibe.ch.
BMJ open
|December 8, 2025
概括
建立一个流行病准备队伍是具有挑战性的,因为最初的入学率很低. 然而,对于参与者和物来说,远程数据收集方法被证明是可行的,这对未来的流行病应对工作至关重要.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 传染病研究 传染病研究
背景情况:
- 及时的流行病学数据对于有效的流行病应对至关重要.
- 随着COVID-19的流行,人们需要通过专门的队伍快速收集数据.
- "伯尔尼,做好准备" (BEready) 研究旨在在瑞士伯尔尼创建一个灵活的流行病准备队伍.
研究的目的:
- 评估建立潜在的流行病准备队伍的可行性和响应率.
- 为未来的流行病情景测试远程数据收集方法.
- 招募包括成年人,儿童和物在内的多元群体.
主要方法:
- 一个封闭的,基于人口的队列试点研究在瑞士伯尔尼.
- 采用私人家庭的随机抽样,包括那些事先参与调查的私人家庭.
- 最初的面对面访问采取血液样本,随后使用在线问卷和自行采集的样本 (毛细血管血液,鼻).
主要成果:
- 试点研究招募了9%的受邀家庭 (108个家庭,193人,44只物).
- 基线样本采集率高 (95%的人,91%的物).
- 一年后的随访实现了高保留率:89%的人和77%的物主人完成了调查,其中88%返回了随访血液样本.
结论:
- 实现高参与者注册的流行病准备队列提出了挑战.
- 远程数据收集方法是可行的,并且对于在面对面接触有限的流行病期间保持数据收集至关重要.
- 尽管招生障碍,但BEready试点研究表明了响应性流行病准备队伍的潜力.
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