内鼻用德克斯米德米丁治疗外科手术期间睡眠障碍:一个系统审查的协议,包括元分析和试验顺序分析
Dan Liu1, Yujie Huang1, Li Du2
1Department of Anesthesiology, West China Hospital, Sichuan University / West China School of Nursing, Sichuan University, Chengdu, Sichuan, China.
BMJ open
|December 8, 2025
概括
这次系统性审查将评估外科手术期间睡眠障碍 (PSD) 的鼻内德克斯梅德托米丁. 它旨在提供证据,证明其在改善睡眠质量和手术后患者结果方面的有效性.
科学领域:
- 麻醉学和外科手术期间的医学.
- 睡眠医学 睡眠医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 术后睡眠障碍 (PSD) 很普遍,并与不良的免疫,认知和长期健康结果有关.
- 由于PSD的高发病率和严重后果,有效管理PSD至关重要.
- 鼻腔内用德克斯梅德托米丁可以改善外科手术后睡眠质量,具有良好的生物可用性和安全性.
研究的目的:
- 进行系统性审查和对鼻内用德克斯米德米丁治疗PSD的疗效进行元分析.
- 综合现有临床证据,以确定鼻内德克斯梅托米丁是否是PSD的有效治疗选择.
主要方法:
- 在2025年10月之前,对多个英语和中文数据库和临床试验注册表进行全面搜索.
- 包括随机对照试验评估内鼻德克斯梅德托米丁PSD.
- 使用Review Manager V.5.4进行统计分析,包括基于异质性评估的固定效应或随机效应模型.
主要成果:
- 数据合成将涉及计算平均差异或风险比率与95%的置信区间.
- 偏差风险和证据质量将使用既有工具进行评估 (Cochrane偏差风险工具V.2,GRADE).
- 试验顺序分析和漏斗图分析将评估证据的确性和出版偏见.
结论:
- 本系统性审查协议概述了一种严格的方法,用于评估内鼻式德克斯米德米丁的PSD.
- 这些发现将提供关键的临床证据,以指导术前睡眠障碍的治疗决策.
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