脑瘤中的聚焦超声波:机制,成像指导和新兴的临床应用
Ali Nabavizadeh1, Kazim Narsinh1, Timothy J Kaufmann1
1From the Department of Radiology (A.N.), University of Pennsylvania, Philadelphia, PA, USA; Department of Radiology and Biomedical Imaging (K.N.), University of San Francisco, San Francisco, CA, USA; Department of Radiology (T.K., S.C.), Mayo Clinic, Rochester, MN, USA; Department of Radiology (H.L., T.B.), National Taiwan University, Taipei City, Taiwan; School of Biomedical Engineering & Imaging Sciences (A.P.), King's College London, London, United Kingdom; Department of Neurosurgery (F.P.), Istituto Neurologico Carlo Besta, Milan, Italy; Department of Neurosurgery (V.A.), Alpheus Medical, Oakdale, MN, USA; Department of Radiological Sciences (B.E., F.S.), Department of Neurosurgery (R.E.), University of California Los Angeles, Los Angeles, CA, USA; Department of Neurosurgery (Y.M.), Sunnybrook Hospital, Toronto, Ontario; Department of Radiology (D.G.), Department of Neurosurgery (G.W.), University of Maryland, Baltimore, MD, USA; Dana-Farber Cancer Institute (P.W.), Boston, MA, USA; Baptist Health (M.A.), Miami, FL, USA; Focused Ultrasound Foundation (N.S., L.P., S.L.), Charlottesville, VA, USA; Department of Radiology and Neurological Surgery (B.S.), University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Biomedical Engineering (C.A.), Georgia Institute of Technology, Atlanta, GA, USA; Department of Neurosurgery (S.M.), University of Virginia, Charlottesville, VA, USA.
聚焦超声波 (FUS) 提供了一种新的,无切口的方法来诊断和治疗像质母细胞瘤 (GBM) 这样的脑瘤,通过增强通过血脑屏障 (BBB) 的药物输送. 这项技术显示出作为标准神经瘤学护理的补充的前景.
科学领域:
- 神经瘤学神经瘤学
- 医学技术 医学技术 医学技术
- 生物物理学的生物物理.
背景情况:
- 尽管目前的治疗方法,像质母细胞瘤 (GBM) 这样的侵袭性脑瘤的预后很差.
- 血脑屏障 (BBB) 显著限制了对脑瘤的治疗.
- 聚焦超声波 (FUS) 为克服这些挑战提供了一个新兴的解决方案.
研究的目的:
- 审查聚焦超声波 (FUS) 在神经瘤学的机制和应用.
- 突出成像在FUS导向治疗中的作用.
- 探索FUS在脑瘤治疗中的未来方向.
主要方法:
- 对神经瘤学中聚焦超声波 (FUS) 现有文献的综述.
- 对FUS机制进行诊断和治疗的分析,包括血脑屏障开放 (BBBO).
- 讨论用于监测FUS治疗和结果的成像方法.
主要成果:
- FUS使无切口的分子诊断,增强药物输送和各种脑瘤的瘤切除成为可能.
- 图像化模式对于确认目标接触,评估生物效应和确保FUS过程中的安全至关重要.
- FUS证明了声动力疗法 (SDT) 和其他新的治疗方法的潜力.
结论:
- 聚焦超声波 (FUS) 是改善脑瘤治疗和诊断的有希望的技术.
- 与液体活检,人工智能和门诊平台的整合将提高FUS在神经瘤学中的实用性.
- FUS准备成为传统神经瘤治疗的宝贵补充.
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