绿色提取的多的自我组装的纳米载体,逐层响应刺激的连续输送:在模拟的胃肠道消化过程中研究稳定性,生物活性和生物可访问性
Marwa Hamdi1, Dandan Wang1, Feng Su1
1College of Chemistry and Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Food research international (Ottawa, Ont.)
|December 8, 2025
概括
研究人员开发了刺激响应层次 (LbL) 纳米颗粒来保护海藻多 (EpEPs). 这些纳米粒子增强了多的稳定性和生物可访问性,对食品和生物医学应用有很大的希望.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 刺激响应层层 (LbL) 纳米载体为提供具有不良溶解性和稳定性的生物活性化合物提供解决方案.
- 针对性药物输送的挑战包括环境敏感性和活性药物成分的低生物可用性.
研究的目的:
- 设计和表征多功能LbL自组装纳米颗粒 (LbL-NP) 用于封装海藻绿色提取的多 (EpEP).
- 研究层次数对纳米粒子结构特征和在各种环境和模拟胃肠道条件下的稳定性的影响.
- 评估通过 LbL-NP 提供的 EpEP 的增强生物可访问性和生物活性.
主要方法:
- 无冲洗层层 (LbL) 自动组装技术用于纳米粒子制造.
- 纳米粒子尺寸,分布和结构组合的表征.
- 在酸性,性,离子强度和温度应力下评估纳米粒子稳定性.
- 在体外评估使用INFOGEST静态模型来模拟胃肠道消化.
主要成果:
- 纳米粒子尺寸从500nm (单层) 增加到990nm (四层),分布均.
- 最佳的四层沉积产生了23%的产量,94.5%的捕获效率和65%的负载能力.
- LbL-NPs证明了EPEPs对环境压力降解的显著保护.
- 观察到EPEPs的保留,生物可访问性 (72%在肠道中) 和生物活性有所改善,并且层数增加.
结论:
- LbL自组装提供了一种有效的方法,用于创建生物活性化合物的刺激响应纳米载体.
- 接口层的数量极大地影响了纳米粒子稳定性和封装聚的抗氧化疗效.
- 这些LbL-NP显示出在食品和生物医学应用中增强多的输送和有效性的巨大潜力.
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