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基转移酶在健康和疾病中的结构,功能和影响

Mattia Ghirardello¹, Inmaculada Yruela^2,3, Pedro Merino^1,4

¹Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), Universidad de Zaragoza, Zaragoza, Spain.

Nature communications

|December 8, 2025

概括

基转移酶 (FUTs) 是细胞通信和免疫中的关键酶. 这篇评论详细介绍了它们的结构,功能和机制,为癌症等疾病的治疗策略提供了洞察力.

科学领域:

生物化学和分子生物学
葡萄糖科学 (Glycoscience) 是一种科学.
结构生物学结构生物学

背景情况:

由fucosyltransferases (FUTs) 催化的基化是一种关键的糖基化过程,影响细胞通信和免疫反应.
了解FUT机制对于破译它们在各种生理和病理条件中的作用至关重要.

研究的目的:

在更高的真核生物中审查fucosyltransferases (FUTs) 的结构和功能多样性.
阐明FUT区域选择性,基质协调和域组织的机制决定因素.
探索FUTs对健康和疾病的影响,并总结治疗策略.

主要方法:

对结构生物学,计算建模和酶工程数据的分析.
人类FUT的遗传学和结构分析.
关于哺乳动物FUT研究和治疗干预的文献综述.

主要成果:

确定了两个主要的人类FUT类别,具有明显的GDP-Fuc识别和形状灵活性,解释了机械差异.
提出了FUT特异性和效率的框架,该框架基于捐赠者诱导的形状变化,外位物相互作用和线索.
突出了FUTs在炎症,免疫和癌症中的作用.

结论:

基转移酶表现出不同的基质识别和催化策略,这对于它们的生物功能至关重要.
结构和工程方法的进步为FUT机制提供了分子洞察力.
准FUT为炎症性疾病和癌症提供了有前途的治疗途径.

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