在DHEA诱导的老鼠模型中,肠-卵巢轴和PCOS的多原子洞察力
Zhi Chen1, Qiongqiong Lu2, Aolei Lin3
1The Department of Gynecology, Chongqing Tradition Chinese Medicine Hospital, No. 6, Qizhi Road, Panxi, Liangjiang District, Chongqing, China. 1050578533@qq.com.
Scientific reports
|December 8, 2025
概括
大鼠的多囊卵巢综合征 (PCOS) 与肠道微生物群和代谢变化有关,特别是在类固醇和脂质通路中. 肠-卵巢轴中的这些干扰可能在PCOS发展中发挥作用.
科学领域:
- 内分泌学 在内分泌学.
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 多囊卵巢综合征 (PCOS) 是一种复杂的内分泌疾病.
- 肠-卵巢轴越来越被认为是PCOS病变的潜在因素.
研究的目的:
- 在PCOS的DHEA诱导大鼠模型中研究肠道微生物群和代谢组的改变.
- 探索肠道失调,代谢障碍和PCOS中的肠卵巢轴之间的联系.
主要方法:
- 通过荷尔蒙和卵巢评估证实,DHEA在老鼠中诱导PCOS.
- 对便,,血清和卵巢组织进行非向的代谢分析.
- 16S rRNA测序用于肠道微生物群的概况.
- KEGG途径分析和代谢物和微生物群之间的相关性研究.
主要成果:
- 在PCOS老鼠中,显著的肠道失调与改变的微生物多样性.
- 在PCOS大鼠中,在多种组织中观察到不同的代谢概况,其中包括类固醇激素和脂质代谢的干扰.
- 关键代谢物如17α-Hydroxyprogesterone和Pregnenolone与改变的肠道细菌 (如Bacillus,Akkermansia) 和PCOS相关的激素相关.
结论:
- 在大鼠中,DHEA诱导的PCOS与显著的肠道微生物群和代谢干扰有关.
- 肠-卵巢轴,涉及改变的肠道细菌和代谢物,可能有助于PCOS的发展.
- 特定的代谢物和微生物变化突出显示了PCOS的潜在治疗点.
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