相关实验视频

Updated: Jan 9, 2026

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Published on: October 22, 2020

吸烟与基因变异结合,调节FOXN3,并与膀癌风险相关

Yiwen Zheng¹, Youhan Wu¹, Jinyue Zhang²

¹The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Key Laboratory of Public Health Safety and Emergency Prevention and Control Technology of Higher Education Institutions in Jiangsu Province, Departments of Environmental Genomics and Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.

Archives of toxicology

|December 8, 2025

概括

福克斯N3基因的遗传变异,特别是rs10484024变异,与膀癌风险增加有关,特别是在吸烟者中. 这一发现突出了FOXN3作为膀癌的潜在生物标志物和治疗点.

科学领域:

遗传学遗传学是一个
在瘤学瘤学.
分子生物学分子生物学

背景情况:

福克斯基因家族 (FOXNs) 在癌症进展中发挥作用,但它们与膀癌风险和遗传变异的具体关联尚不清楚.
了解膀癌的遗传基础对于制定有效的预防和治疗策略至关重要.

研究的目的:

研究FOXN基因的遗传变异与患膀癌的风险之间的关系.
确定与膀癌相关的特定单核酸多态 (SNPs),并探索它们与吸烟等环境因素的相互作用.

主要方法:

在580名膀癌患者和1,101名健康对照中,在FOXN基因中对8,695个SNP进行基因定型.
统计分析以确定显著的风险因素和基因环境相互作用,包括后勤回归和相互作用分析.
功能性注释和基因表达数据 (TCGA,GSE3167) 的分析,以阐明分子机制.

主要成果:

在FOXN3基因的rs10484024T>C变异被确定为膀癌的显著风险因素 (OR=1.18,P=2.72×10−2).
在rs10484024和吸烟之间观察到显著的相互作用 (Pinteraction=3.50×10−2),C等位基因的携带者显示出明显更高的风险 (OR=1.93,P=1.13×10−4).
rs10484024似乎通过影响调节元件来降低FOXN3表达,FOXN3失调与改变的体细胞突变和细胞循环途径有关.

结论:

这项研究确定了FOXN3基因变异与膀癌风险之间的新兴关联,特别突出了rs10484024变异.
与吸烟的显著相互作用强调了基因环境相互作用在膀癌病因学的重要性.
作为膀癌的潜在生物标志物和治疗点,FOXN3值得进一步研究,特别是在吸烟人口中.

关键词:

膀癌是一种癌症.这就是FOXN3N3的意思.基因与环境的相互作用.遗传易感性遗传易感性单核酸多态 (单核酸多态,简称SNP)

更多相关视频

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq

Published on: April 19, 2013

相关概念视频

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...