探索不同配置的肝脏微生理系统的潜力,以模拟胆固醇化学效应

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Updated: Jan 9, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

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Katharina S Nitsche1,2, Courtney Sakolish1, Paul L Carmichael2,3

  • 1Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, 77843, USA.

Archives of toxicology
|December 8, 2025
PubMed
概括

这项研究比较了肝脏模型的药物安全性,发现PhysioMimix LC12微生理系统 (MPS) 在原发性人肝细胞 (PHH) 和HepaRG细胞中有效检测胆固醇酶生物标志物.

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