有模式的无线跨骨光遗传学产生人工感知
Mingzheng Wu1,2, Yiyuan Yang3,4,5,6,7, Jinglan Zhang2
1Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.
Nature neuroscience
|December 8, 2025
概括
研究人员开发了一个微型的大脑-计算机接口,以无线创建人工感知. 这项技术使直接的神经刺激能够实现先进的大脑机器通信和理解大脑感知.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 视觉遗传学 视觉遗传学
背景情况:
- 开发脑机界面 (BMI) 需要在不依赖传统感官路径的情况下创建人工神经输入.
- 一个关键的挑战是建立稳定,最小侵入性,无线控制的人工感知反的平台.
研究的目的:
- 为了展示一个小型化的,可植入的跨骨光遗传神经刺激器,用于实时,无线的皮质合集的模式.
- 通过直接的神经刺激来研究产生人工知觉的可行性.
主要方法:
- 设计并验证了一种微型,完全可植入的跨骨光遗传神经刺激器.
- 利用经过实验验证的数值模拟来进行光和热传播分析.
- 通过体内电生理学和分子方法评估神经元反应.
- 在小鼠的操作学习过程中执行暗示区分任务.
主要成果:
- 成功演示了小鼠感知的人工知觉的无线生成.
- 展示了皮层网络中的空间距离和序列顺序预测了歧视性能.
- 验证了刺激器在引起可测量的神经元反应和行为结果方面的有效性.
结论:
- 这项研究通过实现无线,实时的人工感知生成,在全光脑机通信方面取得了重大进展.
- 开发的技术扩大了对人工模式神经活动及其感知的理解.
- 这些发现为下一代BMI铺平了道路,能够调解人工感知反.
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