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Updated: Jan 9, 2026

Biotin-based Pulldown Assay to Validate mRNA Targets of Cellular miRNAs
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Published on: June 12, 2018

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一个统一的模型,用于微RNA引导的信使RNAs的沉默

Tanmay Chatterjee1, Shankar Mandal1, Sujay Ray1

  • 1Single Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.

Nature communications
|December 8, 2025
PubMed
概括

RNA沉默依赖于miRNA与mRNA的结合. 新的研究揭示了不同的结合状态,表明Ago2结合的miRNA的构造变化调节了RNA沉默疗法的目标识别.

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