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酶B向PET成像在癌症免疫治疗中的应用和前景

Xu Tong¹, Ying Jiang¹, Nan Bi²

¹Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Journal of translational medicine

|December 8, 2025

概括

大酶B (GZMB) 成像提供了一种新的方式来追踪癌症免疫疗法的有效性. GZMB PET提供了对抗瘤免疫力的实时洞察,有助于评估治疗反应和生存预测.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
医疗成像医学成像

背景情况:

评估癌症免疫治疗反应和预测患者的生存率是重大的临床挑战.
由细胞毒性T细胞释放的Granzyme B (GZMB) 是抗瘤免疫的关键作用者.
针对GZMB的正子发射断层扫描 (GZMB PET) 图像提供了一种非侵入性的方法来监测这种免疫活动.

研究的目的:

审查GZMB在抗瘤免疫中的机制.
评估GZMB PET对预测长期生存结果的临床实用性.
将GZMB PET与当前的成像和生物标志物策略进行比较.

主要方法:

文献综述侧重于GZMB在癌症免疫中的功能.
对GZMB PET成像研究的分析及其与治疗反应和存活率的相关性.
对GZMB PET与已建立的诊断和预后工具进行比较评估.

主要成果:

GZMB在T细胞介导的瘤细胞杀死中发挥着关键作用.
GZMB PET成像显示了实时动态监测抗瘤免疫反应的潜力.
对于预测长期结果的传统方法,GZMB PET可能具有优势.

结论:

GZMB PET成像是一种有前途的工具,用于非侵入性评估癌症免疫治疗.
需要进一步的研究,以充分描述GZMB PET的转化前景和临床整合.
在免疫治疗中,GZMB PET有可能完善患者分层和治疗监测.

关键词:

在CAR-T疗法中,癌症免疫疗法癌症免疫疗法大酶B 种子在Granzyme B向的PET成像中使用Granzyme B.免疫检查点抑制剂免疫检查点抑制剂

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