三级阶段优化印米他辛纳米乳液水凝,可持续局部递送,并提高生物疗效
K R Nithin1, G M Pallavi1, K S Srikruthi1
1Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Karnataka, Karnataka, 571448, India.
Scientific reports
|December 8, 2025
概括
这项研究开发了一种带有Indomethacin的纳米乳液水凝 (NEG-IM),用于增强局部伤口愈合. 这种新型配方改善了药物输送,减少了炎症,并对常见的伤口病原体表现出显著的抗菌活性.
科学领域:
- 制药科学 制药科学
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 局部药物输送对于伤口管理至关重要,提供局部治疗,减少全身暴露.
- 印米他辛 (IM) 是一种非类固醇抗炎药物 (NSAID),在伤口愈合期间有效控制炎症.
- 开发像纳米乳液水凝这样的先进配方可以提高药物透率和疗效.
研究的目的:
- 为了制定和表征一个带有Indomethacin的纳米乳液水凝 (NEG-IM) 增强局部伤口愈合.
- 评估NEG-IM的稳定性,药物释放,通过皮肤透和抗菌活性.
- 评估开发的纳米乳液水凝的安全性和细胞吸收.
主要方法:
- 使用三元相图优化纳米乳液配方,其特点是滴滴大小和捕获效率.
- 药物释放研究 (DR) 和透系数 (PC) 测量用于通过皮肤输送的评估.
- 最低杀菌度 (MBC) 测定对大肠杆菌,金黄色杆菌和P. aeruginosa的抗菌有效性.
- 细胞活力测定和细胞吸收研究使用光强度测量.
主要成果:
- 优化的纳米乳液呈现了低于200nm的液滴大小和高捕获效率 (83-88%).
- 与单独的IM相比,NEG-IM表现出显著的通过皮肤传递 (DR 89.78%,PC 0.507 cm2/h) 和优越的抗菌活性.
- 配方显示了良好的细胞活力 (>85%在相关度) 和稳定的细胞内化.
结论:
- 开发的印米他载纳米乳液水凝 (NEG-IM) 是一个有前途的局部配方用于伤口愈合.
- NEG-IM增强了Indomethacin的通过皮肤传递和抗菌特性,提供了安全有效的伤口管理解决方案.
- 这种配方代表了局部NSAID在炎症性伤口状况中的显著进展.
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