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系统注释和分析与疫苗不良事件相关的敏感性基因

Qingyun Song¹, Jun Su¹, Chenchen Pan¹

¹School of Life Health Information Science and Engineering, Chongqing University of Posts and Telecommunications, 2 Chongwen Road, Nanan District, Chongqing, 400065, China.

BMC medical genomics

|December 8, 2025

概括

称为易感基因的遗传变异可以导致疫苗不良事件 (AE). VaegenDB是一个新的数据库,可以帮助研究人员了解这些基因,以便开发更安全的疫苗和个性化免疫.

科学领域:

遗传学是一个遗传学.
免疫学免疫学免疫学
生物信息学是一种生物信息学.

背景情况:

遗传变异,包括单核酸多态性 (SNP),使个体容易发生疫苗不良事件 (AE).
在最初的临床试验中,AE经常被忽视,这凸显了更好地了解易感基因的必要性.
鉴定这些基因对于疫苗的安全性,开发和精确免疫策略至关重要.

研究的目的:

开发VaegenDB,一个集中的数据库和分析系统,用于管理和分析与疫苗AE相关的易感基因.
提供一个用户友好的平台,用于查询和可视化与疫苗AE的遗传关联.
促进生物信息学分析以识别基因特征和理解与疫苗相关的AEs的机制.

主要方法:

精选了基因的基本信息和来自同行评审文献的证据.
从RefSeq和VIOLIN等数据库中自动提取详细的基因,AE和疫苗数据.
开发了一个基于Web的系统,具有交互式查询和可视化功能.
进行KEGG和GO丰富分析以确定功能基因特征.

主要成果:

目前,VaegenDB包含160个易感基因,151个AE和86种疫苗的数据.
生物信息学分析揭示了复杂的关系:单个基因与多个AE相关,单个疫苗与多个AE相关,单个AE与多个基因/SNP相关.
鉴定了与疫苗不良反应相关的丰富基因配置文件和功能注释.

结论:

瓦根DB作为一种有价值的资源,用于了解对疫苗AEs的遗传倾向.
数据库和分析有助于澄清疫苗相关不良事件背后的机制.
这些发现支持合理的疫苗设计和疫苗学精准医学的进步.

关键词:

不良事件是不良事件.生物信息学分析数据库数据库数据库是一个数据库.存在论 (Ontology) 是一种存在论.精准医学是一门精准的医学.易感性基因是一种易感性基因.疫苗疫苗疫苗疫苗

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