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扩展的骨盆淋巴结解剖对术后泌尿控制和神经节约性急性前列腺切除术患者的性功能的影响
Zaisheng Zhu1, Yiyi Zhu2, Hongqi Shi3
1Department of Urology, Jinhua Hospital Affiliated to Zhejiang University School of Medicine, 365 East Renming Road, Jinhua, 321000, Zhejiang, China. zaishengzhu@126.com.
European journal of medical research
|December 8, 2025
概括
在前列腺切除术后扩展的盆腔淋巴结解剖 (ePLND) 不会影响尿路控制,但会显著阻碍性功能恢复. 手术前的因素影响性功能结果.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 外科手术的结果
背景情况:
- 激进前列腺切除术 (RP) 是前列腺癌的主要治疗方法.
- 神经节约技术的目的是保持功能.
- 盆腔淋巴结解剖 (PLND) 对于分期至关重要,延长解剖 (ePLND) 可能有助于改善瘤控制,但也引起了对功能结果的担忧.
研究的目的:
- 评估ePLND对尿路控制 (UC) 和双边神经节约激进前列腺切除术 (RP) 后性功能恢复的影响.
- 为了确定与RP后性功能恢复相关的因素,带有或没有ePLND.
主要方法:
- 一项回顾性研究包括341名接受双边神经节约RP的患者.
- 患者被分为ePLND (n=185) 和没有PLND (n=246) 组.
- 倾向性得分匹配 (PSM) 用于比较组之间的功能结果和并发症,每个匹配组有120名患者.
主要成果:
- 在RP后3,6或12个月,ePLND和没有PLND组之间没有完全UC (0 pad) 的显著差异 (p>0.05).
- 与没有PLND组 (35.9%) 相比,ePLND组 (21.7%) 的性功能恢复到手术前水平较低 (p=0.015).
- 两组之间并发症的发生率相似 (9.2%对4.2%,p=0.121).
结论:
- ePLND不会对术后泌尿控制产生负面影响,也不会增加神经节约性RP后的并发症率.
- 与没有PLND相比,ePLND显著影响性功能恢复.
- 手术前的勃起功能国际指数 (IIEF) -5分,高风险疾病和超扩展的PLND (s-ePLND) 是性功能恢复的独立预测因素.
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