设计了可生物降解的聚合物纳米颗粒可注射系统的阿托瓦斯塔丁,以提高治疗活性
Ramachandran Venkatraman1, Vedha Hari B Narayanan1, Sophia Nowakowski2
1Pharmaceutical Technology Laboratory, School of Chemical & Biotechnology, SASTRA Deemed University, Thanjavur, 613 401, Tamil Nadu, India.
Scientific reports
|December 8, 2025
概括
这项研究使用喷雾干燥开发了可注射的阿托瓦斯塔丁 (ATR) 载荷的奇托桑纳米颗粒. 新型纳米颗粒显著提高ATR的溶解性和透性,提高其治疗高脂血症的潜力.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 阿托瓦斯塔丁 (ATR) 的有效性受到溶解性差和口服生物利用性低的限制.
- 载体介导药物递送系统旨在提高药物的溶解性和生物可用性.
- 这种新型的奇托聚合物是从Portunus Sanguinolentus贝中提取出来的.
研究的目的:
- 通过喷雾干燥合成可注射的Atorvastatin载基托桑纳米颗粒.
- 为了研究喷雾干燥机喷嘴直径和聚合物度对纳米粒子特征的影响.
- 为了评估合成纳米颗粒的体外药物释放,溶解性和体外透性.
主要方法:
- 用于纳米粒子合成的喷雾干燥技术.
- 这是一种从Portunus Sanguinolentus贝中提取的基托桑聚合物.
- 颗粒大小,形态 (SEM),药物载荷,体外释放和体外透研究.
- 使用FT-IR,XRD和TG-DSC进行表征.
主要成果:
- 纳米粒子范围从248.2到329nm,具有很高的药物负载 (>80%).
- 用0.7毫米喷嘴直径实现了更小的颗粒和更高的药物负载.
- 基托桑度的增加导致了更大的颗粒大小,提高了药物的溶解性和透性.
- 药物在聚合物系统内仍然具有功能活性.
结论:
- 合成的阿托瓦斯塔丁载的奇托桑纳米颗粒有效地改善了体外溶解.
- 该配方增强了阿托瓦斯塔丁的溶解性,吸收和透.
- 这种方法有可能改善阿托瓦斯塔丁的体内生物可用性.
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