使用3D打印的基口腔膜增强药物溶解
Dagmar Blaháčková1, Jan Elbl1, Lukas C Lammerding2
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Masaryk University, Palackého třída 1946/1, Brno, 61200, Czech Republic.
The AAPS journal
|December 8, 2025
概括
开发多孔口腔可分散膜 (ODF) 和使用3D打印显著提高了溶解性较差的甲甲的溶解,为改善药物输送提供了有希望的方法.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 药物输送系统 药物输送系统
背景情况:
- 口腔可分散膜 (ODF) 提供方便的药物管理,但难以装载难溶药物.
- 药物装载能力有限阻碍了对具有挑战性的化合物开发的ODF.
- 优化ODF结构对于增强难溶活性药物成分的溶解至关重要.
研究的目的:
- 开发和描述适用于3D打印药用油墨的多孔ODF矩阵.
- 调查宏性对可溶和不可溶药物的药物溶解动力学的影响.
- 通过多孔的ODF和3D打印来增强可溶性较差的德克萨米他的释放.
主要方法:
- 使用溶剂造用和酸盐基原体制造多孔的ODF.
- 通过3D打印将咖啡因和甲加载到ODF中.
- 包括微型CT,BET,SEM,Raman,FTIR,XRD和溶解研究在内的综合性表征.
主要成果:
- 基于的毛孔素使可调节的巨孔性成为可能,支持高药物负载 (3-5倍油墨体积).
- 在多孔的ODF上3D打印的德克萨米他显示出明显增强的溶解 (79.2%),与粉末形式 (29.9%) 相比.
- 容易溶解的咖啡因表现出暂时的溶解延迟,归因于颗粒大小和薄膜分解.
结论:
- 将多孔矩阵设计与3D打印相结合,有效地提高了像甲这样溶解不良的药物的溶解.
- 开发的多孔ODF表现出高的药物负载能力和改善的药物释放概况.
- 对ODF的结构性修改是提高药物溶解的关键驱动因素,而不会产生不良的药物基质相互作用.
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