饮食中的铜摄入量和骨健康:观察性研究的系统审查和元分析
María Auxiliadora Gutiérrez-Guerra1, Luis Manuel Puerto-Parejo2, Elena Pastor-Ramón3
1Socio-Health Sciences Research, University of Extremadura, Cáceres, Spain.
Calcified tissue international
|December 8, 2025
概括
饮食中较高的铜摄入量与腰椎骨矿物质密度 (BMD) 的适度增加有关. 然而,与部BMD的关联仍然不确定的,这表明铜.
科学领域:
- 营养流行病学 营养流行病学
- 骨的新陈代谢 骨的新陈代谢
- 骨质疏松症研究 骨质疏松症研究
背景情况:
- 铜对于原体的交叉链接和骨质生成至关重要,对骨健康至关重要.
- 之前关于饮食中铜摄入量和骨矿物质密度 (BMD) 的研究显示出不一致的结果.
- 了解铜在骨健康中的作用对于营养科学和骨质疏松症预防至关重要.
研究的目的:
- 系统地审查和分析有关饮食中的铜摄入量和BMD的观察性研究.
- 为了澄清习惯性铜消耗与骨部位BMD之间的关联.
- 评估铜对骨质疏松症预防策略的潜在贡献.
主要方法:
- 在主要数据库 (EMBASE,PubMed,OVID,Scopus,Web of Science) 进行系统的文献搜索,截至2025年2月.
- 包括观察性研究评估饮食中的铜摄入量和DXA测量的BMD,遵守PRISMA指南.
- 随机效应元分析用于汇集数据,研究质量通过纽卡斯尔-太华尺度进行评估.
主要成果:
- 三项研究的元分析 (n=9059) 显示,腰椎骨质量在饮食中更高的铜摄入量 (MD 0.02 g/cm2,p=0.04) 的情况下略有显著增加.
- 对四项研究 (n=14,345) 的元分析显示,部BMD (MD 0.02 g/cm2) 的趋势类似,但没有达到统计学意义 (p=0.07).
- 使用Q测试和I2统计来评估异质性,I2值为腰椎的36%和部BMD的74%.
结论:
- 饮食中更高的铜摄入量与改善的腰椎BMD相适度相关.
- 目前,关于饮食中铜摄入量与部骨硬化之间存在显著关联的证据尚不确定.
- 铜可能在骨质疏松症预防中发挥作用,因此需要进一步研究其对骨的影响.
相关概念视频
01:25Role of Vitamins in Maintaining Bone Health
5.0K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.0K
01:20Study Designs in Epidemiology
850
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
850
01:31Essential Minerals for Bone Health
5.9K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
5.9K
01:29Bone Disorders
5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
01:27Urinary Tract Calculi IV: Nutrition Therapy and Prevention
339
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
339
01:31Osteoclasts in Bone Remodeling
3.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.8K