血清ECM1和心脏纤维化在心力衰竭患者之间的相关性
Yanqian Xu1,2, Zhongyuan Han2, Qi Lu3
1Department of Cardiology, Medical School of Nantong University, Chongchuan District, Nantong City, Jiangsu, 226001, PR China.
BMC cardiovascular disorders
|December 9, 2025
概括
细胞外矩阵蛋白1 (ECM1) 和低密度脂蛋白受体相关蛋白1 (LRP1) 的水平升高与心力衰竭 (HF) 进展和心脏纤维化有关. 这些生物标志物可能有助于对HF患者的风险分层.
科学领域:
- 心脏病学 心脏病学
- 生物标志物发现发现
- 分子生物学分子生物学
背景情况:
- 慢性心力衰竭 (HF) 涉及渐进的心肌损伤和重塑.
- 细胞外矩阵蛋白1 (ECM1) 和低密度脂蛋白受体相关蛋白1 (LRP1) 涉及纤维化,但它们在HF中的作用尚不清楚.
研究的目的:
- 调查循环ECM1和LRP1水平与慢性HF患者心脏功能障碍和纤维化标志物之间的关联.
主要方法:
- 一项涉及93名慢性HF患者和80名对照者的横截面研究.
- 血清中ECM1,LRP1,TGF-β1,CTGF和PICP的水平通过ELISA进行测量.
- 统计分析包括组比较,ROC曲线分析和斯皮尔曼相关性.
主要成果:
- 与对照组相比,HF患者的血清ECM1和LRP1水平显著提高 (P < 0.001).
- 在ECM1中,HF的诊断准确度很高 (AUC为0.985).
- 两个ECM1和LRP1水平与心脏功能障碍 (LVEF,NT-proBNP) 和纤维化标志物 (TGF-β1,CTGF,PICP) 相相关.
结论:
- 循环中的ECM1和LRP1在慢性HF中升高,并与心脏功能障碍和纤维化有关.
- ECM1和LRP1显示出作为心肌重塑的新生物标志物的潜力.
- 这些生物标志物可能有助于对HF患者的风险分层和监测.
相关概念视频
Cardiomyopathy IV: Restrictive Cardiomyopathy
431
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
431
Pathophysiology of Heart Failure
2.7K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.7K
Cardiomyopathy III: Hypertrophic Cardiomyopathy
374
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
374
Cardiomyopathy II: Dilated Cardiomyopathy
447
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
447
Heart Failure II: Pathophysiology
685
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
685
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
448
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
448


