对于位置,尺度和形状的联合通用增材模型
Annika Swenne1,2, Timm Intemann3, Luis A Moreno4,5,6,7
1Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstraße 30, Bremen, 28359, Germany. swenne@leibniz-bips.de.
BMC medical research methodology
|December 9, 2025
概括
我们开发了一种增强隐私的位置,规模和形状 (GAMLSS) 的联合通用添加模型,以分析没有物理聚合的分布式数据. 这种方法的结果与传统的GAMLSS相美,确保敏感健康信息的数据隐私.
科学领域:
- 生物统计学 生物统计学
- 计算统计学 计算统计学
- 数据 隐私 数据 隐私 数据
背景情况:
- 位置,尺度和形状 (GAMLSS) 的一般化添加模型对于儿科临床参数百分位曲线估计至关重要.
- 国际百分位曲线需要大型,多样化的数据集,通常是通过汇集多项研究数据来创建的.
- 对共享个人级别敏感数据的伦理和法律限制阻碍了数据聚合.
研究的目的:
- 开发一个增强隐私的联合方法,以适应GAMLSS模型.
- 允许在没有物理传输的情况下共同分析分布式数据,解决数据隐私问题.
主要方法:
- 开发了一个联合的GAMLSS算法,通过DataSHIELD实现分布式数据分析.
- 在R中实现了联合算法,并评估了它的理论属性.
- 将联合GAMLSS应用于分离的流行病学数据,并将结果与聚合数据分析进行比较.
主要成果:
- 从理论和实践上证明,联合的GAMLSS产生的结果与聚合的GAMLSS几乎相同.
- 确定了联合和聚合GAMLSS结果之间的小数值差异.
- 观察到与聚合GAMLSS相比,联合方法的运行时间增加超过1000倍.
结论:
- 提出一种新的增强隐私的联合GAMLSS方法.
- 这种方法允许将GAMLSS模型安装在分布式数据集上,而不会影响数据隐私.
- 联邦GAMLSS提供了一个可行的替代方案,用于推导人口水平的统计数据,当数据聚合是不可行的.
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