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Updated: Apr 30, 2026

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在中优化GAD65114-122对潜在的1型糖尿病抗原特异性免疫治疗的自身抗原

Lei Fu1,2,3,4,5, Kevin Chun Chan1,2,3, Qinglu Zhong2,3,5

  • 1Institute of Urology, The Third Affiliated Hospital of Shenzhen University, Luohu Hospital Group, Shenzhen 518000, China.

The journal of physical chemistry. B
|December 9, 2025
PubMed
概括

研究人员通过增强人类白细胞抗原 (HLA) 结合,为1型糖尿病 (T1D) 疫苗设计了改进的GAD65仿原体. 关键位置的特定突变显著提高了结合亲和力,确定了T1D免疫疗法开发的有希望的候选人.

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