妇女铁生物标志物的周期性波动:铁缺乏症的诊断影响
Sixtus Aguree1, Arthur Owora2,3, Patricia Silveyra4,5
1Department of Applied Health Science, Indiana University School of Public Health-Bloomington, Bloomington, IN, USA.
Practical laboratory medicine
|December 9, 2025
概括
铁的生物标志物和缺铁性贫血 (IDA) 的患病率在整个月经周期中波动,在月经期间最低. 了解这些变化可以改善女性对铁状况的评估.
科学领域:
- 生殖健康 生殖健康
- 营养生物化学 营养生物化学
- 血液学 血液学 血液学
背景情况:
- 缺铁 (ID) 和缺铁性贫血 (IDA) 在生育年龄的女性中很普遍.
- 月经周期阶段对铁生物标志物的影响在临床评估中经常被忽视.
研究的目的:
- 为了检查铁生物标志物水平和ID和IDA的患病率在不同月经周期阶段如何变化.
- 用2003-2006年NHANES数据集分析18-44岁的非怀孕妇女的数据.
主要方法:
- 分析了1484名妇女的数据,这些妇女拥有完整的生殖和铁状况信息.
- 月经周期分为四个阶段的分类:月经,卵泡,早期/中期和晚期.
- 评估八个铁生物标志物,包括血清铁,转蛋白和度,费里丁和血红蛋白,使用已建立的模型定义了ID和IDA.
主要成果:
- 血清铁和转林和在月经期间是最低的,在黄体阶段增加.
- 在月经期间,可溶性转移素受体水平最高,这表明铁的需求增加.
- 虽然ID患病率没有显示出一致的阶段变化,但月经后IDA患病率下降,从7.5%降至3.7%.
结论:
- 铁生物标志物水平和IDA患病率在整个月经周期中呈现系统变化.
- 铁的状态在月经期间是最低的,在黄体阶段得到改善.
- 将月经期纳入铁生物标志物的解释可能会提高生殖年龄妇女的诊断准确度.
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