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在拥有物家庭的儿科眼皮表面微生物组

Xiangtian Ling¹, Charlene C Yim^1,2,3, Qihang Sun¹

¹Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.

Current research in microbial sciences

|December 9, 2025

概括

家庭物改变了儿科的眼表面微生物群 (OSM). 物暴露增加了微生物多样性,并激活了免疫路径,可能会影响儿童的过敏发展.

科学领域:

眼科医生眼科眼科
微生物学微生物学
免疫学免疫学免疫学

背景情况:

物暴露与儿童过敏有关.
物对儿科眼表面微生物群 (OSM) 的影响尚不清楚.
OSM可能会调解眼睛免疫力.

研究的目的:

为了调查由于家庭物接触而导致儿科OSM的变化.
探索物暴露与OSM组成和功能之间的关系.

主要方法:

在347名儿童 (5-15岁) 的横截面研究中.
结节的16SrRNA测序. 结节的测序.
生物信息学和功能预测分析 (QIIME2,DADA2,SILVA 138,PICRUSt2) 进行.

主要成果:

暴露于物的儿童显示出更高的OSMα多样性 (Shannon,Simpson,观察指数).
在接触物儿童中观察到明显的β多样性和丰富的属 (Streptococcus,Actinomyces,Neisseria).
在接触过物儿童中,增强了NF-κB和VEGF信号通路;在未接触过物儿童中,增加了类生物合成.

结论:

物暴露改变了儿科的OSM,增加了多样性和环境类型.
NF-κB和VEGF通路激活表明了与物相关的免疫调节的新机制.
OSM的变化可能会影响儿童的眼表面健康和过敏敏感性.

关键词:

微生物多样性的微生物多样性.眼睛表面的微生物组儿科眼科儿科眼科物暴露物暴露

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