来自草游泳膀的新型多目标ACE抑制:识别和潜在的抗高血压机制
Ye Dong1, Chengcheng Li2, Yi-Qi Zhang2
1College of Food Science and Technology, Zhejiang Pharmaceutical University, Ningbo, China.
Food chemistry: X
|December 9, 2025
概括
研究人员从草鱼游泳膀副产品中发现了新的抗高血压. 这种可持续的方法将水产养殖废物用于功能性食品和药品.
科学领域:
- 生物技术和食品科学 生物技术和食品科学
- 生物化学和分子生物学
- 可持续的水产养殖可持续的水产养殖
背景情况:
- 水产养殖副产品代表了大量未充分利用的生物质来源.
- 开发循环生物经济模型对于可持续的食品系统至关重要.
- ангиотензин转化酶 (ACE) 抑制剂是管理高血压的关键标.
研究的目的:
- 为了识别草游泳膀水解剂中的新型ACE抑制性.
- 为了验证一个集成的in silico-in vitro查策略用于发现.
- 评估已识别的的抗高血压潜力和稳定性.
主要方法:
- 综合性在体 (分子对接,动力学) 和体外 (酶抑制试验,动力学研究) 查.
- 草的水解游泳膀和分离.
- 网络药理学分析以预测治疗点.
主要成果:
- 两种新型的ACE抑制,FPSPFR和LWDPPEGAP,被确定具有81.34微米和206.91微米的IC50值.
- 体表现出非竞争性抑制,优异的胃肠道稳定性,并通过分子对接表现出强大的结合亲和力.
- 通过与多个核心标的相互作用,FPSPFR显示出潜在的抗高血压作用.
结论:
- 综合的in silico-in vitro策略有效地识别了强大的 ACE 抑制.
- 草游泳膀衍生的是一种可持续的抗高血压功能成分来源.
- 这项研究支持利用渔业副产品用于食品和制药应用.
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