与代谢功能障碍相关的脂肪性肝病和2型糖尿病之间存在密切的多层次联系
A G Holleboom1,2, S M Francque3,4, K Cusi5
1Department of Vascular Medicine, Amsterdam UMC, the Netherlands.
Metabolism open
|December 9, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 和2型糖尿病 (T2DM) 密切相关,胰岛素抵抗驱动这两种疾病. 新兴疗法显示,在同时治疗MASLD和T2DM方面具有前途.
科学领域:
- 肝病学和内分泌学.
- 代谢疾病 代谢疾病
- 肝纤维化研究 肝纤维化研究
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 的患病率和严重程度正在上升,与肥胖和2型糖尿病 (T2DM) 有关.
- MASLD和T2DM具有强烈的流行病学和机制联系,主要是由胰岛素抵抗驱动的.
- MASLD的进展可能导致肝衰竭和肝细胞癌,同时也与发生的T2DM有关.
研究的目的:
- 为了突出MASLD和T2DM之间的复杂关系.
- 讨论胰岛素抵抗作为一种常见的机制性途径的作用.
- 审查针对MASLD-T2DM接口的新兴药理学策略.
主要方法:
- 流行病学数据分析将MASLD和T2DM的流行率和严重程度联系起来.
- 审查了阐明胰岛素抵抗作用的机制研究.
- 对药理学药剂和针对共同途径的治疗策略的调查.
主要成果:
- 二型糖尿病与MASLD患病率,严重程度和进展到晚期肝病的增加有关.
- MASLD与患T2DM的风险增加有关.
- 药理学药物,如基于印克雷丁的策略,FGF21类似物和兰尼纤维素,显示出改善MASH和肝纤维化的潜力.
结论:
- MASLD和T2DM是相互关联的,胰岛素抵抗是核心因素.
- 涉及肝病学家,糖尿病学家和PCP的综合护理方法对于管理纤维化MASLD至关重要.
- 未来的管理策略应该通过协作努力来解决MASLD和T2DM的双重负担.
相关概念视频
01:36Carbohydrate Metabolism
13.7K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.7K
01:24Overview of Lipid Metabolism
4.7K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
4.7K
01:20Pathophysiology of Diabetes
3.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.1K
01:30Liver Physiology
3.4K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.4K
01:22Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
01:19Overview of Carbohydrate Metabolism
3.2K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
3.2K