农业农业法实施揭示了隐藏的狂犬病负担:实施前后的分析和与菲律宾的非实施地点的比较
Nobuo Saito1,2,3,4, Patricia T Lacanilao1, Alyssa M Garcia1
1Research Center for Global and Local Infectious Diseases, Oita University, Yufu, Oita, Japan.
One health (Amsterdam, Netherlands)
|December 9, 2025
概括
使用侧流装置 (LFD) 的分散狂犬病诊断在菲律宾显著增加了病例检测. 这种改善的监测和疫情应对措施,尽管持续的"一个健康"方法仍然是一个挑战.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 狂犬病诊断依赖于实验室检测,通常是集中的,限制了流行地区的监测.
- 侧流装置 (LFD) 对狂犬病诊断有前途,但它们对分散监控的影响需要评估.
研究的目的:
- 评估LFD在去中心化,低资源环境中的诊断性能.
- 评估LFD实施对菲律宾狂犬病监测和病例检测的影响.
主要方法:
- 在菲律宾狂犬病流行地区建立了分散的诊断实验室.
- 与直接光抗体测试 (DFAT) 相比,评估了LFD诊断准确性.
- 使用中断时间序列分析分析了LFD实施前和后狂犬病病例检测率的变化.
主要成果:
- 与DFAT相比,LFD显示出高灵敏度 (97.0%) 和特异性 (98.2%).
- 每月确诊的狂犬病病例在LFD实施后增加了4.14倍 (p < 0.001).
- 虽然LFD引发了调查,确定了其他未接种疫苗的咬伤受害者和暴露的动物,但整合的One Health调查很少 (5.6%).
结论:
- 基于LFD的去中心化显著提高了狂犬病病例检测和当地疫情应对能力.
- LFD是控制狂犬病在特有环境中的有价值的工具.
- 在LFD检测出狂犬病病例后,维持综合调查的一种健康方法仍然是一个挑战.
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