慢性多部位疼痛和失眠患者的死亡率增加:HUNT研究
Jonas Bloch Thorlund1,2, Tom Ivar Lund Nilsen3,4, Eivind Schjelderup Skarpsno3
1Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Sleep medicine: X
|December 9, 2025
概括
慢性多部位疼痛与失眠相结合,与较高的全因死亡率有关. 解决这些患者的失眠问题可能会改善健康结果并降低死亡风险.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 睡眠医学 睡眠医学
背景情况:
- 失眠在患有慢性肌肉骨疼痛的人中很普遍.
- 慢性疼痛和失眠都独立地与增加的死亡风险有关.
- 慢性多部位疼痛和失眠对全因死亡率的综合影响仍未得到充分研究.
研究的目的:
- 调查慢性多部位疼痛和失眠症状与全因死亡率之间的联合关联.
- 量化这些条件同时出现所带来的死亡风险.
主要方法:
- 利用了来自挪威HUNT研究 (第3波,2006-2008) 39545名参与者的数据.
- 将参与者数据链接到国家死亡原因登记处以查看死亡结果.
- 使用Cox比例危险模型来计算危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 患有慢性多部位疼痛和失眠的个体,与没有失眠的无疼痛个体相比,所有原因死亡率的危险比率 (HR) 为1.21 (95% CI 1.01-1.43).
- 没有失眠的慢性多部位疼痛没有显著增加死亡风险 (HR 1.00,95% CI 0.91-1.11).
- 没有慢性疼痛的失眠不会显著增加死亡风险 (HR 1.05,95% CI 0.83-1.34),并且没有观察到协同效应.
结论:
- 慢性多部位疼痛和失眠的同时发生与全因死亡率的增加有关.
- 这些发现表明,治疗慢性疼痛患者的失眠可能有助于改善整体健康状况.
- 进一步的研究可能会探索针对睡眠质量的干预措施,以减轻这一群体的死亡风险.
相关概念视频
Insomnia
381
Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
Multiple factors contribute...
381
Management of Insomnia
507
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
507
Analgesia and Pain Management
1.4K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.4K
Sedatives and Hypnotics Drugs: Miscellaneous Agents
479
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
479
Insufficient Sleep and Sleep Deprivation
807
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
807
Substance Use Disorders Affecting Sleep
369
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
369


