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肝星状细胞衍生的IL-11 通过HSC和巨细胞之间的相互作用加剧肝纤维化

Yu Zhang1,2, Fangfang He1,2, Mozi Lei1,2

  • 1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

International journal of biological sciences
|December 9, 2025
PubMed
概括

由肝星细胞衍生出来的INTERLEUKIN-11 (IL-11) 通过激活肝星细胞和重编程巨细胞来驱动肝纤维化. 治疗性抑制IL-11可缓解纤维化,并逆转巨细胞极化.

关键词:
它们是IL-11和IL-11.细胞与细胞的相互作用.肝脏的恒星细胞.肝脏纤维化 肝脏纤维化巨细胞是什么?巨细胞是什么?

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