H3K27 乙化驱动的IGF2BP2 在MSC老化过程中发生突变,从而影响骨质分化和骨老化

Zimo Zhou1, Kai Kang2, Heran Wang1

  • 1Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

概括

介质干细胞 (MSC) 的表观遗传变化驱动骨老化. 使用CWI1-2准H3K27ac-IGF2BP2-HMGA1通路可能可以治疗骨质疏松症.

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