减少的强度与有肠道衰竭史的儿童的异常身体组成有关
Dianna Yanchis1,2, Stephanie So1,2,3, Catherine Patterson1,2,3
1Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
Journal of pediatric gastroenterology and nutrition
|December 9, 2025
概括
患有肠衰竭 (IF) 的儿童与正常人相比,肌肉强度降低. 力量与身体组成有关,较低的无脂肪质量与力量的减少相关,特别是在男性中.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 儿科内分泌学 儿科内分泌学
- 儿科物理治疗 儿科物理治疗
背景情况:
- 关于肠道衰竭 (IF) 的儿科患者身体组成和肌肉力量之间的关系的数据有限.
- 这项研究通过评估FI儿童的力量及其与身体组成的相关性来解决知识差距.
研究的目的:
- 根据既定规范,评估FI儿童的肌肉和功能力量.
- 在这个群体中调查身体组成指标和力量参数之间的关联.
主要方法:
- 31名患有FI的儿童 (4-18岁) 用布鲁宁克斯-奥塞雷茨基运动能力-2 (BOT-2) 测试和通过手握力 (HGS) 和膝盖动力学测试的肌肉力量来评估功能强度.
- 使用双能X射线吸收计 (DXA) 确定身体成分.
- 统计分析包括t测试用于组比较和线性回归来探索身体组成与力量的关系.
主要成果:
- 与已公布的标准相比,患有IF的儿童的HGS,膝盖曲和伸展强度显著降低 (p <0.05).
- 很大一部分参与者在所有力量测量中得分低于平均水平 (80.6%的HGS,71.0%的膝盖曲,74.2%的伸展).
- 功能强度与无脂肪质量正相关,与脂肪质量反相关 (r2 = 0.36,p = 0.002),这种关系在男性中更强 (r2 = 0.62,p < 0.001).
结论:
- 与健康对照人群相比,患有肠道衰竭的儿科患者表现出普遍的软弱,不管使用了哪种营养支持方法 (肠道营养或亲肠道营养).
- 减少无脂肪质量是与FI儿童强度下降相关的关键因素.
- 在男性中,身体构成和力量之间的更强的关联要求进一步研究潜在的生理机制.
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