向骨质疏松症:常规负载的proniosomes及其在卵巢切除的老鼠中OPG/RANKL调制中的作用

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Abeer Salama¹, Amira Mohamed Mohsen², Asmaa Badawy Darwish²

¹Pharmacology Department, National Research Centre, Cairo, Egypt.

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概括

常规载荷的proniosomes (Rutin-PNs) 通过改善骨密度,有效地治疗卵巢切除的老鼠的骨质疏松症. 这种新的配方增强了 rutin 的功效.

科学领域:

药理学和药物输送药理学和药物输送
生物医学工程生物医学工程
骨生物学骨生物学骨生物学

背景情况:

骨质疏松症是一个重要的健康问题,特别是在绝经后的妇女中.
目前治疗骨质疏松症的方法有局限性,需要新的治疗方法.
鲁丁是一种天然的黄类化合物,具有潜在的抗骨质疏松性质,但需要有效的输送系统.

研究的目的:

开发和描述用于骨质疏松症治疗的Rutin载荷proniosomes (Rutin-PNs).
为了研究Rutin-PNs在卵巢切除的老鼠模型中的活体疗效.
评估Rutin-PNs对关键骨代谢标志物的影响.

主要方法:

使用同化相分离方法合成了例行PNs.
亲子体的特征是捕获效率 (EE%),粒子大小 (PS),泽塔潜力 (ZP) 和体外释放.
在活体研究中,参与过卵巢切除的老鼠接受了Rutin-PNs治疗一个月.

主要成果:

常规PNs显示高EE% (65.8591.25%) 和合适的PS (371.3533.8nm) 和ZP (-22.1到-40.7mV).
在体内实验的结果显示,骨骨干的厚度和密度有所改善.
常规PNs显著调节了OPG,BMP2,Smad-1,RANKL和ALP的水平.

结论:

开发的Rutin-PNs增强了 rutin 的抗骨质疏松活性.
常规PNs代表了一种有前途的替代治疗药物,用于绝经后骨质疏松症的管理.
亲体药物递送系统可以提高天然化合物对骨健康的疗效.

关键词:

这是OPG/RANKLL.一个常规的日常生活.骨质疏松症是一种骨质疏松症.进行卵巢切除.它们是前基因体.鼠类鼠类鼠类鼠类鼠类

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