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抗氧化维生素与精神障碍之间的关系:一个元分析

Hua Pan¹, Wenhui Xu¹, Motong Liu¹

¹Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China. haitaoyu@jlu.edu.cn.

Food & function

|December 9, 2025

概括

这项元分析发现,抑郁症患者的饮食和血液中抗氧化剂维生素A,C和E的水平较低.精神分裂症患者也显示血液中维生素C和E的水平较低,精神分裂症和维生素C之间存在因果关系.

科学领域:

营养精神病学营养精神病学
心理健康研究心理健康研究
生物化学生化学

背景情况:

精神障碍越来越多地与氧化压力有关.
抗氧化剂维生素A,C和E具有已知的抗氧化特性.
抗氧化剂维生素状况与精神健康状况之间的确切关系需要进一步澄清.

研究的目的:

将注意力缺陷多动症 (ADHD),自闭症谱系障碍 (ASD),抑郁症和精神分裂症 (SZ) 患者的抗氧化剂维生素A,C和E的饮食和血液水平与健康对照进行比较.
通过使用孟德尔随机化 (MR) 来研究这些抗氧化维生素和心理健康状况之间的潜在因果关系.

主要方法:

进行了一项元分析,比较患者组和对照组之间的维生素A,C和E水平 (饮食和血液).
使用孟德尔随机化 (MR) 后元分析来评估因果关系.
统计分析包括标准化平均差异 (SMD) 和置信区间 (CI).

主要成果:

与对照组相比,患有抑郁症的患者饮食摄入维生素A,C,E和胡卜素的摄入量显著降低.
抑郁症患者也表现出维生素A,C和E的血液水平降低.
精神分裂症患者的血液中维生素C和维生素E水平有所降低.
在患有ADHD或ASD的患者中,没有观察到抗氧化维生素水平的显著差异.
根据MR分析,精神分裂症和维生素C之间存在因果关系.

结论:

患有抑郁症的人在饮食和血液中缺乏抗氧化剂维生素A,C和E.
精神分裂症患者的血液中维生素C和维生素E水平较低.
这些发现突出了抗氧化维生素在抑郁症和精神分裂症患者的心理健康中的潜在作用.

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