特拉马多尔用于治疗神经性咳:一个回顾性的案例系列
Benjamin Joseph Rubinstein1, Sheela Saidha1, John Todd Sinacori1
1Macon & Joan Brock Virginia Health Sciences Eastern Virginia Medical School, Old Dominion University, Norfolk, VA, USA.
特拉马多尔有效治疗成年人的神经性咳,许多人经历了显著的症状减轻. 药物一般耐受性很好,一些患者可以随着时间的推移停止治疗.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 咳的药物 咳的药物
背景情况:
- 神经性咳是一种具有挑战性的疾病,通常不耐标准治疗.
- 探索新型治疗剂对于治疗慢性咳至关重要.
研究的目的:
- 评估特拉马多尔治疗神经性咳的疗效和安全性.
- 描述长期治疗结果和患者对特拉马多尔的体验.
主要方法:
- 对用特拉马多尔治疗的神经性咳的成年患者进行了回顾性病例系列分析.
- 定义完整响应为咳停止和部分响应为>=50%的严重程度/频率降低.
主要成果:
- 包括69名患者;38%的完整反应,33%的部分反应.
- 每天两次服用50毫克是最有效的治疗方案;镇静是最常见的副作用 (10%).
- 喉手术史与较低的应答率相关 (p=0.04).
结论:
- 特拉马多尔在治疗神经性咳方面表现出潜在的有效性.
- 这种药物一般耐受性很好,有很大一部分患者能够停止治疗.
- 进一步的研究可能会支持特拉马多尔作为神经性咳的可行选择.
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