相关实验视频

Updated: Jan 9, 2026

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Published on: November 28, 2018

作为TIPS前扩张性功能障碍的预测者,可以预测TIPS后的结局在肝硬化患者中

Shoma Bommena¹, Jason Patel², Pooja Rangan³

¹Division of Gastroenterology and Hepatology, University of Arizona College of Medicine-Tucson, Banner University Medical Center, Tucson, Arizona, USA.

Liver international : official journal of the International Association for the Study of the Liver

|December 9, 2025

概括

2020年循环心肌病 (CCM) 透支功能障碍 (DD) 标准确定了患有TIPS后并发症风险较高的患者. 与较旧的标准不同,2020年CCMDD定义预测了诸如心血管事件和器官功能障碍等不良结果.

科学领域:

心脏病学心脏病学
肝病学肝病学是一种肝病学.
胃肠病学胃肠病学

背景情况:

扩张性功能障碍 (DD) 在缺乏补偿的肝硬化患者中很常见.
根据2020年循环性心肌病 (CCM) 指南定义的DD的临床意义,经过横性肝内移植系统分流 (TIPS) 放置后,尚不清楚.
以前的DD标准可能不准确地反映了这个人群中的风险.

研究的目的:

评估2020年CCM DD标准与TIPS后结果之间的关联.
为了比较2020年CCMDD标准对TIPS后不良事件的2005年DD标准的预测值.

主要方法:

一项多中心回顾性研究包括261名在2018年至2022年期间接受TIPS的成年患者.
在TIPS之前的6个月内,对2020年CCMDD标准 (≥3的:E/e≥15,隔膜e<7cm/s,TRV>2.8m/s,LAVI>34mL/m2) 进行了患者的评估.
使用后勤回归模型分析与TIPS后结果的关联,与2005年DD标准进行比较 (DT>200 ms,IVRT>80 ms,E/A <1).

主要成果:

只有6.9%的患者符合2020年CCMDD标准. 这些患者年龄较大,高血压和MASLD的发病率较高.
满足2020年CCMDD标准与心血管事件 (aOR 6.7),功能障碍 (aOR 3.7) 和肝功能障碍 (aOR 7.4) 的几率显著增加有关.
2005年的DD标准 (75.8%的患者满足) 显示,与TIPS后的结果没有关联.

结论:

根据2020年CCM标准的定义,扩张功能障碍是早期TIPS后并发症的重要预测因素.
2020年CCM DD标准与2005年标准不同,有效地识别了TIPS后发生不良事件风险增加的肝硬化患者.
符合2020年CCMDD标准的患者可能会受益于TIPS后更密切的监测,因为它们与年龄,高血压,MASLD和β-阻断剂使用有关.

关键词:

心血管事件的发生.肝硬化心肌病症肝硬化心肌病症门高血压门高血压脏功能障碍脏功能障碍

更多相关视频

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Published on: August 1, 2018

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

相关概念视频

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...

Cardiomyopathy II: Dilated Cardiomyopathy

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

Mitral Regurgitation IV: Nursing Management

Mitral Regurgitation IV: Nursing Management

Mitral regurgitation (MR) is a condition where the mitral valve does not close properly, leading to the backward flow of blood from the left ventricle into the left atrium during systole. This condition can arise from various causes, including rheumatic fever, infective endocarditis, or degenerative valve disease. Effective nursing management is crucial to optimizing patient outcomes and involves comprehensive assessment and targeted interventions.Comprehensive Patient AssessmentA detailed...

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...