相关实验视频

Updated: Jan 9, 2026

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
10:08

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain

Published on: August 28, 2012

12.2K

压力诱导的抗体聚合物:来自本地SEC-MS的洞察力与后列变性

Daniil Ivanov1, Christine Lee1, Dennis Delgado1

  • 1Sanofi R&D, Framingham, Massachusetts 01701, United States.

Journal of the American Society for Mass Spectrometry
|December 9, 2025
PubMed
概括

本研究介绍了一种使用本地SEC-MS的平台方法,用于在压力单克隆抗体 (mAb) 治疗中表征高分子量物种 (HMWS). 该方法有效地区分了共价和非共价聚合物,有助于降解途径研究.

关键词:
这是一个HMWS.这是一个PCDPCD.美国证券交易委员会-MS.聚合物 聚合物 聚合物降解途径的降解途径这是一种单克隆抗体.本地MSMS国家压力研究研究研究压力研究.

更多相关视频

Rapid Generation of Amyloid from Native Proteins In vitro05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

6.5K
One-step Purification of Twin-Strep-tagged Proteins and Their Complexes on Strep-Tactin Resin Cross-linked With Bissulfosuccinimidyl Suberate BS318:27

One-step Purification of Twin-Strep-tagged Proteins and Their Complexes on Strep-Tactin Resin Cross-linked With Bissulfosuccinimidyl Suberate BS3

Published on: April 20, 2014

19.5K

相关概念视频

SDS-PAGE01:27

SDS-PAGE

Gel electrophoresis is a method that separates biological macromolecules like nucleic acids or proteins by forcing them to pass through a gel matrix under an electric field.
A variation of gel electrophoresis, termed  polyacrylamide gel electrophoresis (PAGE), is commonly used for separating proteins according to their molecular size by passing them through a polyacrylamide gel. Because of the varying charges associated with amino acid side chains, PAGE can be used to separate intact...
32.7K