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阿克尔曼西亚尼菲拉通过塑造内毒素耐受性巨细胞表型来减轻败血症引起的免疫抑制

Hang Qian¹, Fei Zhao²

¹Intensive Care Unit, Zhuji Affiliated Hospital of Wenzhou Medical University, Zhuji City 311800, China.

Pathogens and disease

|December 9, 2025

概括

阿克尔曼西亚菌 (AKK) 通过调节巨细胞表型来逆转败血症引起的免疫抑制. 这种肠道益生菌增强了细菌清除,为败血症提供了潜在的治疗策略.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
胃肠病学胃肠病学

背景情况:

败血症是一种危及生命的疾病,涉及免疫抑制,通常与内毒素耐受性有关.
肠道微生物群,包括Akkermansia muciniphila (AKK),在免疫调节中发挥作用.

研究的目的:

调查AKK在败血症引起的免疫抑制中的作用.
确定AKK对巨细胞两极分化和细菌清除的影响.

主要方法:

16S rRNA测序用于评估免疫抑制个体的AKK水平.
使用RAW 264.7巨细胞进行体外研究,以评估AKK对内毒素耐受性和M2/M1表型的影响.
在内毒素耐受性小鼠模型中的体内实验,以评估AKK的治疗潜力.

主要成果:

在免疫抑制个体中观察到AKK水平的降低.
在体外,AKK治疗逆转了内毒素耐受性诱导的M2巨细胞两极分化到M1表型.
AKK增强了Pseudomonas aeruginosa的清除,并在体内减轻了免疫抑制.

结论:

AKK调节巨细胞极化,从免疫抑制的M2表型转变为M1表型.
通过打击免疫抑制和改善细菌清除,AKK显示出作为败血症治疗剂的潜力.

关键词:

阿克尔曼西亚的木偶生活.耐受性耐受性内毒素耐受性免疫抑制是一种免疫抑制.巨细胞是什么?巨细胞是什么?这是一种血症.

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