有机 (II) J-聚合物具有延长三倍寿命,用于增强光动力学和光催化疗法
Dan Li1, Xiuyang Wang1, Tao Jin2
1College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, 518060, China.
Angewandte Chemie (International ed. in English)
|December 9, 2025
概括
有机 (II) 复合物形成J-聚合物,通过改善电子接受和系统间交叉来增强光疗. 这些J-聚合物有效地根除癌细胞,并在体内抑制瘤生长.
科学领域:
- 材料科学 材料科学 材料科学
- 摄影化学的使用.
- 生物医学工程 生物医学工程
背景情况:
- J-聚合物比单体具有增强的光疗特性.
- 在J-聚合物光疗增强背后的机制需要进一步阐明.
研究的目的:
- 为了研究有机 (II) 复合物的自我组装到J-聚合物.
- 阐明对增强光疗法负责的光物理机制.
- 在体外和体内评估J-聚合物的治疗疗效.
主要方法:
- 合成和表征近红外 (NIR) 发射的有机复合物 (Pt-2TPE, Pt-2TPA).
- 理论计算以确定LUMO能量水平和单元-三元能量差距.
- 暂时吸收光谱测量三倍激发状态寿命.
- 关于活性氧物种 (ROS) 生成和细胞根除的体外研究.
- 使用生物素修饰的纳米配方 (Biotin@Pt-2TPA) 抑制瘤的体内研究.
主要成果:
- 通过Pt-Pt和π-π堆叠,Pt-2TPE和Pt-2TPA通过Pt-Pt和π-π堆叠自组合成J聚合物.
- J-聚合物表现出较低的LUMO水平和减少的单元-三元能量差距,增强电子接受和系统间交叉 (ISC).
- 与单体 (123 ns) 相比,J-聚合物显示出明显延长的三重激发状态寿命 (Pt-2TPA为5.8μs).
- 在红光下通过J-聚合物有效生成ROS和催化NADH氧化.
- 在正常和缺氧条件下有效根除B16-F10细胞.
- 生物@Pt-2TPA纳米配方在体内显示出显著的瘤积累和生长抑制.
结论:
- 有机 (II) 复合物的J聚合通过改善的光物理性质提高了光疗效率.
- J-聚合物战略为开发先进的光动力学和光催化疗法提供了一个有前途的方法.
- 这项研究提供了一种可行的策略,用于增强 (II) 复杂基光疗.
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