具有高负载效率和稳定性的工程化多层质酸性脂质体,用于增强透皮输送
Wanping Zhang1,2, Zhe Li2, Xun Bu2
1Collaborative Innovation Center of Fragrance Flavour and Cosmetics, School of Perfume and aromtechnology, Shanghai Institute of Technology, Shanghai 201418, China.
Langmuir : the ACS journal of surfaces and colloids
|December 9, 2025
概括
多质皮质脂质体 (MCL) 提供一种稳定,无刺激的通过皮肤递送药物溶液. 这些新型脂质体表现出增强的透性和高封装效率,用于像视网醇这样的治疗药物.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 药品制造 药品制造 药品制造
背景情况:
- 阴阳性脂质体 (CLs) 由于其生物降解性和透性,是有前途的药物载体.
- 与CLs的挑战包括刺激,稳定性和有效的透皮输送.
研究的目的:
- 开发稳定,无刺激的多叶膜酸性脂质体 (MCLs) 以提高通过皮肤传递.
- 为了研究分子组合,并描述开发的MCLs的特性.
主要方法:
- 使用大豆莱西丁,胆固醇和聚醇溶剂中的阴离子表面活性剂来制备MCL.
- 分子组件使用异热定位热量计 (ITC) 和2D-ROESY.使用研究.
- 安全性和有效性通过的胆膜测定和猪耳皮浸透性研究来评估.
主要成果:
- MCLs表现出类似洋的结构,大小约300纳米,高泽塔电位 (40-60mV).
- 的胆膜测定显示出最小的出血 (ESI <12),表明无刺激性.
- 带有雷丁醇的MCL实现了80.29%的封装,并且在猪皮肤中显示出明显更高的累积释放率.
结论:
- 开发的MCL提供了一个稳定高效的跨皮药物输送平台.
- 这种配方克服了传统的CL的主要局限性,提供了更好的安全性和有效性.
- MCLs代表了下一代透皮系统的战略进步.
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