作为辅助治疗的益生菌可以改善DSS诱导的大肠炎和肠道微生物群
Yan Kong1, Peitong Cao1, Jie Wu1
1Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Microbiology spectrum
|December 9, 2025
概括
益生菌与独家肠道营养 (EEN) 结合,通过改善肠道微生物群,有效治疗小鼠结肠炎. 果子-寡糖 (FOS) 显示出最好的结果,为炎症性肠病 (IBD) 的临床应用提供了一个有前途的基础.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群失调与炎症性肠道疾病 (IBD) 有关.
- 益生菌可以改善肠道微生物群,但它们与IBD专用肠道营养 (EEN) 的组合需要进一步研究.
- 在IBD患者中,EEN具有可变的治疗益处和对肠道微生物群的不良影响.
研究的目的:
- 为了研究EEN与益生菌结合在治疗小鼠中德克斯硫酸盐 (DSS) 诱导的大肠炎的疗效.
- 评估EEN和益生菌组合对肠道微生物群结构和组成的影响.
- 为了比较不同益生菌 (异多氧糖,果糖糖,多) 的治疗效果,当作为辅助疗法使用EEN时.
主要方法:
- 用4%的DSS诱导大肠炎的小鼠.
- 在一周的时间里,小鼠接受了普通水,EEN,EEN + isomaltooligosaccharide (IMO),EEN + fructo-oligosaccharide (FOS) 或EEN + polydextrose (POL) 的治疗.
- 评估了临床结果 (疾病活动指数,结肠长度,组织学得分) 和肠道微生物群组成.
主要成果:
- 与EEN单独相比,与益生菌相结合的EEN在缓解DSS诱导的大肠炎方面显示出更大的益处.
- 果酸寡糖 (FOS) 在降低疾病活性指数和预防结肠缩短方面表现出优异的有效性.
- 益生菌辅助疗法显著降低了组织学分数和调节了肠道微生物群结构,POL增强了辛普森指数,IMO改善了F/B比率.
结论:
- 作为辅助疗法的益生菌,特别是FOS,显著改善了DSS诱导的大肠炎的临床结果.
- 结合EEN和益生菌有效调节肠道微生物群的结构和组成.
- 这些发现为临床应用益生菌作为IBD的辅助疗法提供了科学基础.
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