由于Whipple病引起的关节内心炎:亚急性内心炎的罕见原因
Laura Valentina López-Gutiérrez1, Gustavo Adolfo Castilla-Agudelo2, Luisa Fernanda Durango-Gutiérrez2
1Universidad Pontificia Bolivariana-Clínica CardioVID, Medellín, Colombia.
JACC. Case reports
|December 9, 2025
概括
威普尔病是一种罕见的细菌感染,可以导致培养负性内心炎,特别是影响心脏门. 通过活检早期诊断和及时的抗生素治疗对于管理这种严重疾病至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
- 胃肠病学 胃肠病学
背景情况:
- 惠普尔病是一种罕见的慢性感染,由Tropheryma whipplei引起.
- 它可以呈现为培养负的传染性内心炎,通常涉及大动脉.
研究的目的:
- 要突出一个怀普尔病的病例,呈现为培养负的米特拉内心炎.
- 强调在无法解释的内心炎中考虑惠普尔病的重要性.
主要方法:
- 一名45岁的男性患有慢性腹,减肥和关节炎,患上心力衰竭.
- 心声扫描显示了心交膜质量; 血液培养是负的.
- 十二指肠活检通过阳性周期性酸-希夫染色证实了惠普尔病.
主要成果:
- 用多西环素和氧化成功治疗导致临床和心声学改善.
- 该病例表明Tropheryma whipplei内心炎没有典型的全身特征.
结论:
- 具有全身或胃肠道症状的培养负内心炎需要考虑惠普尔病.
- 诊断依赖于组织病理学或PCR;治疗涉及长时间的抗生素,可能是手术.
- 识别这种罕见的病因对于有效和及时的患者管理至关重要.
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