Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.9K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.9K
Hematopoiesis01:21

Hematopoiesis

8.5K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
8.5K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.8K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.8K
Lineage Commitment01:21

Lineage Commitment

4.0K
Commitment is the  process whereby stem cells:
4.0K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

8.2K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
8.2K
Production of Formed Elements01:34

Production of Formed Elements

3.6K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
3.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Proteome Responses to Acute Inhibition of De Novo Sphingolipid Synthesis Suggest Cancer Combination Therapies.

Cancers·2026
Same author

Glycosphingolipids regulate phosphatidylserine transport machinery that operates at ER-PM contact sites.

Nature communications·2026
Same author

RUNX1+23 Enhancer Marks Erythro-Megakaryocyte Lineages in Early Waves of Hematopoiesis in Human ESC Differentiation.

Blood advances·2026
Same author

Transcranial vibrotactile stimulation enhances hippocampal cholinergic signaling and memory through frequency-dependent mechanotransduction.

Scientific reports·2026
Same author

KRAS Inhibition Activates an Actionable CD24 "Do Not Eat Me" Signal in Pancreatic Cancer.

Cancer research·2025
Same author

Terraforming the KRAS lipid landscape.

Nature chemical biology·2025

相关实验视频

Updated: Jan 9, 2026

Analysis of Hematopoietic Stem Progenitor Cell Metabolism
12:20

Analysis of Hematopoietic Stem Progenitor Cell Metabolism

Published on: November 9, 2019

7.3K

机理代谢指导造血干细胞的规范.

Paulina D Horton1,2,3, Alina Syed1, Michelle Winkler1,3

  • 1Department of Integrative Biology & Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.

The Journal of experimental medicine
|December 9, 2025
PubMed
概括

来自血液流动的机械力塑造了血液生成干细胞前体中的线粒体功能. 这种机理代谢适应对血液发育和潜在的疾病治疗至关重要.

更多相关视频

Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer
10:17

Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer

Published on: September 24, 2021

3.1K
Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
11:00

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

Published on: December 16, 2016

7.6K

相关实验视频

Last Updated: Jan 9, 2026

Analysis of Hematopoietic Stem Progenitor Cell Metabolism
12:20

Analysis of Hematopoietic Stem Progenitor Cell Metabolism

Published on: November 9, 2019

7.3K
Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer
10:17

Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer

Published on: September 24, 2021

3.1K
Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
11:00

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

Published on: December 16, 2016

7.6K

科学领域:

  • 发展生物学 发展生物学
  • 细胞生物学 细胞生物学
  • 血液形成 血液形成 血液形成

背景情况:

  • 众所周知,机械力量,特别是血液流动,会影响造血干细胞 (HSC) 的发展.
  • 物理力量调节内皮细胞转化为血液构造细胞的分子机制在很大程度上仍然不清楚.
  • 了解这些机制对于控制HSC命运和功能至关重要.

研究的目的:

  • 为了研究血流的剪切应激如何影响线粒体动态和功能在血源性内皮.
  • 阐明分子途径,包括mTOR信号传递,参与力介导的造血命运决定.
  • 探索操纵机械代谢对HSC工程的治疗潜力.

主要方法:

  • 分析线粒体的组成,超结构和在剪切应力条件下的功能.
  • 研究基因转录和蛋白质合成,特别是含有5'TOP动机的转录,以应对层状流.
  • 利用拉巴胺素 (mTOR) 途径调节器和遗传模型 (心跳突变) 的机械标来评估血液形成.

主要成果:

  • 剪切应激会导致线粒体功能和结构的显著适应,这对于造血命运至关重要.
  • 层状流促进了与核糖体相关的转录的翻译,表明增强了蛋白质合成.
  • mTOR通路的激活对于流量响应性代谢重编程和HSC潜力至关重要;其化学诱导在体内部分挽救了血液形成.

结论:

  • 机械代谢,机械力和代谢途径之间的相互作用,是造血干细胞命运的关键决定因素.
  • 针对mTOR途径和线粒体适应提供了一个新的策略来设计HSC.
  • 这些发现对疾病建模和再生医学中的治疗应用有意义.